DrugFriday: Omeprazole


Omeprazole belongs to the class Proton Pump Inhibitors (PPIs), commonly used for treatment of gastritis, dyspepsia or what is known as “Acidity” in lay terms.

Mechanism Of Action:

PPIs bind to the proton pump in gastric parietal cells, resulting in suppression of basal and stimulated acid secretion.


Omeprazole metabolism is mainly through liver. It is non dialysable.


  • Acute gastritis
  • Peptic ulcer disease – gastric and duodenal ulcers
  • Erosive esophagitisesophagitis
  • GERD
  • Zollinger Ellison and other hypersecretory conditions
  • In burns, surgery, sepsis or major stressful conditions to the body to prevent stress ulcers.


  1. Duodenal Ulcer: 20 mg once daily for 4-8 weeks
  2. Helicobacter Pylori Infection: Various regimens exist of PPIs combined with antibiotics eg. 20 mg twice a day for 10 days, with Amoxicillin 1000 mg 12 hourly, and Clarithromycin 500 m 12 hourly for 10-14 days
  3. Gastric Ulcer: 40 mg once daily for 4-8 weeks daily
  4. GERD 20 mg once daily for 4 weeks
  5. Erosive Esophagitis: 20 mg once daily for 4-8 weeks


20 mg once Daily for up to 1 year

Zollinger-Ellison Syndrome 60 mg once daily (initial) up to 360 mg/day divided q8hr PO

If dose >80 mg, divide it.

Adverse Effects

  • Headache
  • Abdominal pain
  • Diarrhea
  • Nausea
  • Vomiting
  • Flatulence
  • Dizziness
  • Constipation
  • Rash


Main interactions are with anti HIV drugs, iron preparations, anti virals, anti fungals etc.

Use In Pregnancy:

Its a category C drug in pregnant women where use is with caution if benefit outweighs risk.

Common Brands

Omez, Acicheck, Acidoff


Please enter your comment!
Please enter your name here